GLP-1 receptor agonists like Ozempic (Semaglutide), Mounjaro (Tirzepatide), and Wegovy have revolutionized medical weight loss. But at Refine by Tulsi, we recognize that these medications aren’t meant to be a lifelong solution—whether for clinical, lifestyle, or financial reasons.
However, studies show that when patients stop GLP-1 medications abruptly, they could regain up to 70% of their lost weight. Why? Because these medications impact hunger, metabolism, and insulin response—and without a proper transition, your body may struggle to maintain the progress you’ve made.
At Refine by Tulsi, Dr Kotecha has been working with numerous patients to develop a personalized, science-backed weaning protocols to help patients maintain their weight loss while gradually reducing reliance and cost associated with GLP-1s.
Weaning-Off Strategy
There is no one-size-fits-all approach, but our method focuses on stabilizing metabolism, controlling hunger, and addressing underlying weight gain factors.
1. Increasing Time Between Doses
GLP-1 medications have a long half-life, meaning they stay in your system for extended periods. We gradually increase the time between injections to minimize withdrawal effects while allowing your body to adjust.
2. Dose Optimization & Microdosing
Instead of stopping suddenly, we reduce dosage in small, controlled increments. This allows your metabolism and appetite regulation to adapt naturally without sudden cravings or energy crashes.
3. Strengthening Lifestyle & Nutrition
GLP-1s make it easier to lose weight—but lasting success requires sustainable habits:
✔ Balanced Macronutrients – We focus on protein intake to maintain muscle mass and prevent metabolic slowdowns.
✔ Mindful Eating – Without medication controlling hunger, we guide patients to recognize true hunger signals and avoid binge cycles.
✔ Blood Sugar Stability – Monitoring glucose levels prevents insulin resistance and unwanted fat storage.
4. Exercise & Muscle Building to Improve Metabolism
Muscle mass plays a crucial role in weight maintenance. We emphasize:
✔ Strength Training – Building lean muscle prevents metabolic decline post-GLP-1.
✔ Cardiovascular Fitness – Optimizing endurance for fat-burning efficiency.
✔ Post-Workout Recovery – Preventing muscle loss while transitioning off medication.
5. Targeting the Root Causes of Weight Gain
Many patients struggle with underlying metabolic, hormonal, or gut health imbalances. At Refine by Tulsi, we investigate and address these factors to create a long-term, personalized weight management plan:
✔ Hormonal Testing – Identifying thyroid, cortisol, and sex hormone imbalances.
✔ Microbiome Analysis – Gut bacteria play a huge role in metabolism and weight regulation.
✔ Insulin Resistance & Blood Sugar Control – Preventing post-GLP-1 weight rebound.
The Goal: A Smooth, Sustainable Transition
At Refine by Tulsi, we believe weight loss success is not just about losing weight—it’s about keeping it off.
✔ We help you transition off GLP-1 medications safely and strategically.
✔ We focus on metabolism, muscle retention, and long-term sustainability.
✔ We guide you through medical testing, lifestyle changes, and targeted interventions to prevent rebound weight gain.
Thinking about weaning off GLP-1s but worried about regaining weight? Schedule a consultation with Dr. Kotecha today to develop a personalized plan for long-term success.
